Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1
نویسندگان
چکیده
منابع مشابه
Hsa-microRNA-101 suppresses migration and invasion by targeting Rac1 in thyroid cancer cells
MicroRNAs (miRNAs) are 22- to 25-nucleotide non-coding RNA molecules that function as negative regulators of gene expression. In previous years, increasing evidence has arisen implicating the involvement of miRNAs in carcinogenesis. In previous studies, the role of miRNA-101 (miR-101) in tumors has been identified as a tumor suppressor and, until now, the role of miR-101 and Rac1 in thyroid can...
متن کاملSilencing of the long non-coding RNA NEAT1 suppresses ovarian cancer cell proliferation, migration and invasion
Increasing evidence reveals that long noncoding RNAs (lncRNAs) are involved in the development of various human cancers including ovarian cancer. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is an essential structural determinant of nuclear body paraspeckles. Although aberrant expression and prognostic value of NEAT1 has been recently reported in various human cancers, NEAT1 was not fu...
متن کاملOverexpression of long non-coding RNA loc285194 suppresses cell proliferation and migration in hepatocellular carcinoma
The expression pattern of long non-coding RNA (lncRNA) has been reported to be a new player in various diseases, including cancer. Aberrant expression of these genes will affect tumorigenesis through either oncogenic or tumor suppressive pathways. Hepatocellular carcinoma (HCC), with the increasing incidence, has become the second deadly cancer in men and the sixth in women in the world. Given ...
متن کاملdendrosomal curcumin upregulates expression of the long non-coding rna gene meg3 in u87mg glioblastoma cells
objective:glioblastoma is an invasive tumor of the central nervous system. epigenetic therapy of cancer is potentially very useful in reversing some of cancer defects due to reversibility of epigenetic alterations. meg3 is a tumor suppressor long non-coding rna (lncrna) that expresses in the majority of normal tissues. methylation of the meg3 promoter region elicits a decrease in its expression...
متن کاملmiR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2.
Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, miR-204 expression was found to be down-regulated, and that of Janus ki...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neoplasma
سال: 2015
ISSN: 1338-4317
DOI: 10.4149/neo_2015_065